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| Research article summary (published 30 Mar 2003): |
White matter tract alterations in fragile X syndrome: preliminary evidence from diffusion tensor imaging.
Full Abstract
Fragile X syndrome, the most common form of hereditary mental retardation, causes disruption in the development of dendrites and synapses, the targets for axonal growth in the central nervous system. This disruption could potentially affect the development, wiring, and targeting of axons. The current study utilized diffusion tensor imaging (DTI) to investigate whether white matter tract integrity and connectivity are altered in fragile X syndrome. Ten females with a diagnosis of fragile X syndrome and ten, age matched, female control subjects underwent diffusion weighted MRI scans. A whole brain analysis of fractional anisotropy (FA) values was performed using statistical parametric mapping (SPM). A follow-up, regions-of-interest analysis also was conducted. Relative to controls, females with fragile X exhibited lower FA values in white matter in fronto-striatal pathways, as well as in parietal sensory-motor tracts. This preliminary study suggests that regionally specific alterations of white matter integrity occur in females with fragile X. Aberrant white matter connectivity in these regions is consistent with the profile of cognitive and behavioral features of fragile X syndrome, and potentially provide additional insight into the detrimental effects of suboptimal levels of FMRP in the developing brain.Copyright 2003 Wiley-Liss, Inc.
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Author information
Author/s: Barnea-Goraly, Naama (N); Eliez, Stephan (S); Hedeus, Maj (M); Menon, Vinod (V); White, Christopher D (CD); Moseley, Michael (M); Reiss, Allan L (AL);
Affiliation: Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5719, USA.
Grants: HD 31715 (Agency:United States NICHD) ; MH 01142 (Agency:United States NIMH) ; MH 50047 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), published in United States. (Language: eng)
Reference: 2003-Apr; vol 118B (issue 1) : pp 81-8
Dates: Created 2003/03/10; Completed 2003/07/14; Revised 2008/05/21;
PMID: 12627472, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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