Research article summary (published 29 Jun 2003):

Waiting for ON: a major problem in patients with Parkinson disease and ON/OFF motor fluctuations.

Full Abstract

The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations:
time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.

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Author information

Author/s: Merims, Doron (D); Djaldetti, Ruth (R); Melamed, Eldad (E);

Affiliation: Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Clinical neuropharmacology (Clin Neuropharmacol), published in United States. (Language: eng)

Reference: -2003 Jul-Aug; vol 26 (issue 4) : pp 196-8

Dates: Created 2003/08/04; Completed 2003/09/10; Revised 2006/11/15;

PMID: 12897640, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Antiparkinson Agents - administration & dosage Drug Administration Schedule Female Humans

Male Middle Aged Movement Disorders - drug therapy; physiopathology Parkinson Disease - drug therapy; physiopathology Reaction Time - physiology

Associated Chemicals: Antiparkinson Agents (0)

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