 |
| Research article summary (published 27 Feb 2002): |
Volumetric MRI measurements can differentiate Alzheimer's disease, mild cognitive impairment, and normal aging.
Full Abstract
BACKGROUND:
Volumetric magnetic resonance imaging (MRI) has been extensively studied in the last decade as a method to help with the clinical diagnosis of Alzheimer's disease (AD). In recent years, researchers have also started investigating if that technique would be useful to identify individuals with mild cognitive impairment (MCI), differentiating them from AD patients and from normal elderly controls. This research project was planned to assess the accuracy of volumetric MRI to differentiate those groups of individuals.
METHOD:
The investigation involved 39 patients with diagnosis of mild to moderate dementia in AD, according to the criteria of the NINCDS-ADRDA, DSM-III-R, and ICD-10; 21 subjects with complaints of cognitive decline without other psychiatric disorders (MCI); and 20 normal elderly controls. All the subjects were submitted to a standard protocol, including volumetric MRI evaluations.
RESULTS:
The results indicated that all regions of interest measured (amygdala, hippocampus, and parahippocampal gyrus) were significantly different (p < .005) in AD patients compared to MCI subjects and controls. The left volumetric measures (amygdala, hippocampus, and parahippocampal gyrus) were also significantly different between the MCI subjects and controls (p < .05). The discriminant function analysis correctly classified 88.14% of the AD patients and controls, 81.67% of AD patients and MCI subjects, and 80.49% of the MCI subjects and controls.
CONCLUSIONS:
The results suggest that measures of medial temporal lobe regions are useful to identify mild to moderate AD patients and MCI subjects, separating them from normal elderly individuals.
Learn Faster Today Improve your study skills
Author information
Author/s: Bottino, Cássio M C (CM); Castro, Cláudio C (CC); Gomes, Regina L E (RL); Buchpiguel, Carlos A (CA); Marchetti, Renato L (RL); Neto, Mário R Louzã (MR);
Affiliation: Institute and Department of Psychiatry, University of São Paulo School of Medicine, Brazil. cbottino@usp.br
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
Journal: International psychogeriatrics / IPA (Int Psychogeriatr), published in United States. (Language: eng)
Reference: 2002-Mar; vol 14 (issue 1) : pp 59-72
Dates: Created 2002/07/03; Completed 2002/12/13; Revised 2006/11/15;
PMID: 12094908, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.