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Your query 'vitro pharmacological characterization methyl pyrrolidinyl' matched 214188 abstracts with 315790 hits. Returning the first 200 results.

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Articles 1 to 10 of 200:

In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist.

20 Nov 2007 Activation of the prostaglandin E(2) (PGE(2)) EP(4) receptor, a G-protein-coupled receptor (GPCR), results in increases in intracellular cyclic AMP (cAMP) levels via stimulation of adenylate cyclase. Here we describe the in vitro pharmacological ...
rec_pub_18155068-in-vitro-pharmacological-characterization-cj-042794-novel-potent.htm

Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist.

26 Jul 2008 (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), is a subtype-selective neuronal nicotinic acetylcholine receptor (nAChR) agonist. In rodents, SIB-1508Y exhibited antidepressant activity, reversed age-related ...
rec_pub_18692487-pharmacological-characterization-s-2-5-ethynyl-3-1-methyl-2.htm

In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine.

18 Dec 2006 The pharmacological properties of mitemcinal (GM-611), the first acid-resistant non-peptide motilin agonist, were investigated in the smooth muscle of the rabbit small intestine and compared with porcine motilin (pMTL), erythromycin A (EMA) and its ...
rec_pub_17183187-in-vitro-pharmacological-characterization-mitemcinal-gm-611-acid.htm

In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

Jul 2007 Novel isoxazolopyridone derivatives that are metabotropic glutamate receptor (mGluR) 7 antagonists were discovered and pharmacologically characterized. 5-Methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one (MDIP) was identified by random ...
rec_pub_17609420-in-vitro-pharmacological-characterization-novel-isoxazolopyridone.htm

In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects.

13 Oct 2005 Tyrosine kinases are used as important biomarkers in many tumor types. Preclinical and clinical anti-tumor studies have shown that broadly acting tyrosine kinase inhibitors may be more useful than specific inhibitors, since the former might ...
rec_pub_16096368-in-vitro-pharmacological-characterization-tki-28-broad-spectrum.htm

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

5 Aug 2006 BACKGROUND AND PURPOSE: The CB2 receptor has been proposed as a novel target for the treatment of pain, and CB2 receptor agonists defined in in vitro assays have demonstrated analgesic activity in animal models. Based on its in vivo analgesic ...
rec_pub_16894349-in-vitro-pharmacological-characterization-am1241-protean-agonist.htm

Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375.

29 Jun 2005 1. SB-706375 potently inhibited [(125)I]hU-II binding to both mammalian recombinant and 'native' UT receptors (K(i) 4.7+/-1.5 to 20.7+/-3.6 nM at rodent, feline and primate recombinant UT receptors and K(i) 5.4+/-0.4 nM at the endogenous UT ...
rec_pub_15852036-nonpeptidic-urotensin-ii-receptor-antagonists-vitro-pharmacological.htm

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.

18 Apr 2005 We report the cloning, molecular characterization, and pharmacological characterization of the canine 5-HT2A and 5-HT2B receptors. The canine and human 5-HT2A receptors share 93% amino acid homology. The canine and human 5-HT2B receptors are also ...
rec_pub_15862800-molecular-pharmacological-characterization-serotonin-5-ht2a-5-ht2b.htm

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization.

30 Mar 2007 Numerous studies document that melatonin possesses a broad-spectrum antioxidant activity. It traps a number of reactive oxygen species (ROS) such as hydroxyl and peroxyl radicals, singlet oxygen and hypochlorous acid. It also inhibits ...
rec_pub_17439554-no-donor-melatonin-derivatives-synthesis-vitro-pharmacological.htm

Acute intravenous injection toxicity study of IBZM and BZM in rats.

30 Dec 2007 S-3-iodo-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (IBZM) is one of the several benzamide derivatives showing a high affinity for the central nervous system (CNS) D2 dopamine receptor. Carrier-free [123I]IBZM is potentially ...
rec_pub_18850361-acute-intravenous-injection-toxicity-study-ibzm-bzm-rats.htm

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