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| Research article summary (published 29 Jun 2002): |
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Vitamin E and cognitive decline in older persons.
Full Abstract
BACKGROUND:
Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases.
OBJECTIVE:
To examine whether intake of antioxidant nutrients, including vitamin E, vitamin C, and carotene, is associated with reduced cognitive decline with age.
DESIGN:
Longitudinal population-based study conducted from September 17, 1993, to November 20, 2000, with an average follow-up of 3.2 years.
PATIENTS:
The patients were 2889 community residents, aged 65 to 102 years, who completed a food frequency questionnaire, on average 18 months after baseline.
MAIN OUTCOME MEASURE:
Cognitive change as measured by 4 tests (the East Boston Memory Test, which tests immediate and delayed recall; the Mini-Mental State Examination; and the Symbol Digit Modalities Test) at baseline and 3 years for all participants, and at 6 months for 288 randomly selected participants.
RESULTS:
We used random-effects models to estimate nutrient effects on individual change in the average score of the 4 cognitive tests. The cognitive score declined on average by 5.0 x 10(-2) standardized units per year. There was a 36% reduction in the rate of decline among persons in the highest quintile of total vitamin E intake (-4.3 x 10(-2) standardized units per year) compared with those in the lowest quintile (-6.7 x 10(-2) standardized units per year) (P =.05), in a model adjusted for age, race, sex, educational level, current smoking, alcohol consumption, total calorie (energy) intake, and total intakes of vitamin C, carotene, and vitamin A. We also observed a reduced decline with higher vitamin E intake from foods (P =.03 for trend). There was little evidence of association with vitamin C or carotene intake.
CONCLUSION:
Vitamin E intake, from foods or supplements, is associated with less cognitive decline with age.
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Author information
Author/s: Morris, Martha Clare (MC); Evans, Denis A (DA); Bienias, Julia L (JL); Tangney, Christine C (CC); Wilson, Robert S (RS);
Affiliation: Department of Preventive medicine, Rush Institute for Healthy Aging, Rush-Presbyterian-St Luke's Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA. mmorris@rush.edu
Grants: AG11101 (Agency:United States NIA) ; AG13170 (Agency:United States NIA)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Archives of neurology (Arch Neurol), published in United States. (Language: eng)
Reference: 2002-Jul; vol 59 (issue 7) : pp 1125-32
Dates: Created 2002/07/15; Completed 2002/07/26; Revised 2007/11/14;
PMID: 12117360, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Arch Neurol. 2003 Feb;60(2):292-3; author reply 293. (PMID: 12580722)
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