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| Research article summary (published 30 Jul 2002): |
Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P.
Full Abstract
We investigated the visual event-related potentials (ERPs) in two subtypes of multisystem atrophy (MSA) in 15 MSA-C patients, 12 MSA-P patients, and 21 normal control (NC) subjects. We used a visual oddball task to elicit ERPs. No significant changes were seen in N1 or N2 latency, in either MSA-C or MSA-P, compared with the NC group. An early stage of visual information process related to N1 and a visual discrimination process related to N2 might be preserved in both MSA-C and MSA-P. The P3a peak was more frequently undetectable in MSA than in the NC group. Significant P3a amplitude reduction in both MSA-C and MSA-P suggests impairment of the automatic cognitive processing in both MSA-C and MSA-P. Significant difference was found in P3b latency and P3b amplitude only in MSA-C, compared with the NC group. The result suggests the impairment of the controlled cognitive processing after the visual discrimination process in the MSA-C group. We further investigated the correlation between visual ERP changes and magnetic resonance imaging (MRI) data. Quantitative MRI measurements showed reduced size of the pons, cerebellum, perisylvian cerebral area, and deep cerebral gray matter in both MSA-C and MSA-P, and of the corpus callosum only in MSA-P, as compared to NC group. In both MSA-C and MSA-P, P3b latency was significantly correlated with the size on MRI of the pons and the cerebellum. P3b latency in the whole MSA group was also significantly correlated with the size of the pons and the cerebellum. These results indicate that P3b latency changes in parallel with the volume of the pons and the cerebellum in both MSA-C and MSA-P.
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Author information
Author/s: Kamitani, Toshiaki (T); Kuroiwa, Yoshiyuki (Y); Wang, Lihong (L); Li, Mei (M); Suzuki, Yume (Y); Takahashi, Tatsuya (T); Ikegami, Tadashi (T); Matsubara, Sho (S);
Affiliation: Department of Neurology, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Japan.
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of neurology (J Neurol), published in Germany. (Language: eng)
Reference: 2002-Aug; vol 249 (issue 8) : pp 975-82
Dates: Created 2002/08/26; Completed 2002/12/23; Revised 2006/11/15;
PMID: 12195440, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: J Neurol. 2003 Aug;250(8):1001-3. (PMID: 12928926)
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