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| Research article summary (published 30 Aug 2003): |
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Vertical optokinetic nystagmus and saccades in normal human subjects.
Full Abstract
PURPOSE:
Optokinetic stimulation induces nystagmus that can be used to test the saccadic and visual-tracking systems in some patients with voluntary gaze palsies. The purpose of this study was to characterize vertical optokinetic nystagmus (OKN) in normal human subjects, comparing the dynamic properties of the quick phases with voluntary saccades of similar size and measuring the slow-phase responses to visual stimuli with a range of spatial and temporal frequencies.
METHODS:
Vertical OKN and saccades were recorded in 10 healthy adult subjects (age range, 24-54 years) using the magnetic search coil technique. The optokinetic (OK) stimulus subtended 72 degrees horizontally and 60 degrees vertically, consisted of black-and-white stripes with a spatial frequency of 0.04, 0.08, or 0.16 cyc/deg, and moved vertically at 10 to 50 deg/s. Vertical and horizontal saccades to visual targets separated by 1 degrees to 10 degrees were also elicited.
RESULTS:
Over 95% of quick phases were less than 10 degrees in amplitude; voluntary saccades of this amplitude range were slightly faster than quick phases of similar size. The amplitude-peak velocity relationships and amplitude-duration relationships of upward and downward fast movements (saccades or quick phases) were similar. Most vertical slow-phase OK responses showed greater gain for upward stimulus motion. OK gain decreased with increasing stimulus speed and increased spatial frequency, so that there was a general decrease in slow-phase velocity gain with increasing temporal frequency.
CONCLUSIONS:
In this study, the best OK responses were obtained using stripes with lower spatial frequencies and lower stripe speeds (0.4 cyc/deg at 10 deg/s). The dynamic properties of vertical quick phases of nystagmus are similar enough to those of voluntary saccades for OK stimulation to be used as a clinical test of the vertical saccadic system in individuals with voluntary gaze palsy.
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Author information
Author/s: Garbutt, Siobhan (S); Han, Yanning (Y); Kumar, Arun N (AN); Harwood, Mark (M); Harris, Chris M (CM); Leigh, R John (RJ);
Affiliation: Department of Neurology, Department of Veterans Affairs Medical Center and University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Grants: EY06717 (Agency:United States NEI)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci), published in United States. (Language: eng)
Reference: 2003-Sep; vol 44 (issue 9) : pp 3833-41
Dates: Created 2003/08/26; Completed 2003/09/16; Revised 2007/11/14;
PMID: 12939299, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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