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| Research article summary (published 30 Mar 2002): |
Verbal memory in left temporal lobe epilepsy: evidence for task-related localization.
Full Abstract
We explored the hypothesis that components of verbal memory are subserved by separate temporal lobe structures in patients with temporal lobe structures in patients with temporal lobe epilepsy [correction]. Uptake of 18F-fluorodeoxyglucose (FDG) measured by positron emission tomography, hippocampal volume, and memory for arbitrarily and semantically related verbal paired associates were examined in 27 patients with left temporary lobe epilepsy. Scores from memory tests performed outside the scanner were regressed against normalized resting FDG uptake at each voxel. Significant regression was seen in the left perirhinal cortex (Talaraich coordinates x, y, z:
-29, 10, -34; p < 0.05) for arbitrarily related word pairs. For semantically related paired associates, significant regression was present in the left inferior temporal gyrus (x, y, z:
-48, -18, -24; p < 0.05). In subsequent analyses, mean FDG uptake within a spherical region of interest centered on the perirhinal peak predicted performance on both tasks. Mean FDG uptake in a region of interest centered on the inferior temporal peak made an additional, independent contribution to memory for semantically related pairs. Hippocampal volumes did not explain any additional variance in memory scores. Our findings indicate that heterogeneity in the left temporal lobe structures mediating verbal memory function, and support the view that the perirhinal cortex is an important mnemonic substrate.
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Author information
Author/s: Weintrob, David L (DL); Saling, Michael M (MM); Berkovic, Samuel F (SF); Berlangieri, Salvatore U (SU); Reutens, David C (DC);
Affiliation: Department of Psychology, The University of Melbourne, Australia.
Journal and publication information
Publication Type: Journal Article
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2002-Apr; vol 51 (issue 4) : pp 442-7
Dates: Created 2002/03/28; Completed 2002/04/18; Revised 2004/11/17;
PMID: 11921050, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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