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| Research article summary (published 30 Dec 2001): |
Verbal fluency facilitated by the cholinergic blocker, scopolamine.
Full Abstract
This study was designed to explore putative facilitatory effects of low doses of scopolamine (SP) on phonemic (letter) and semantic (category) verbal fluency. A double-blind, parallel-group design was used with 36 subjects who completed a test battery before and 2 h after 0.6 mg or 1.2 mg of SP or placebo. Fluency measures included total number of words generated, clustering (the production of words within semantic or phonemic subcategories) and switching (the ability to shift efficiently to new subcategories). Low doses of scopolamine increased phonemic fluency, as has been shown previously. Semantic fluency was not increased by SP, although subjects treated with 1.2 mg of SP generated higher-frequency words. SP did not affect clustering or switching. It is suggested that phonemic and semantic fluency reflect distinct cognitive processes.Copyright 2002 John Wiley & Sons, Ltd.
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Author information
Author/s: Pompéia, S (S); Rusted, J M (JM); Curran, H V (HV);
Affiliation: Department of Psychobiology, UNIFESP, São Paulo, Brazil.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal: Human psychopharmacology (Hum Psychopharmacol), published in England. (Language: eng)
Reference: 2002-Jan; vol 17 (issue 1) : pp 51-9
Dates: Created 2002/10/29; Completed 2003/01/13; Revised 2008/03/06;
PMID: 12404707, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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