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| Research article summary (published 16 Jul 2003): |
Ventromedial prefrontal cortex activation is critical for preference judgments.
Full Abstract
Preference judgment, the process of selecting a response from several alternatives based on which alternative the subject likes best, is an important aspect of daily life. The current study examined whether neural substrates that are thought to be critical for generating somatic markers are involved in preference judgments. Fifteen healthy, right-handed subjects performed a preference judgment task during functional magnetic resonance imaging. The medial frontal gyrus was significantly more activated during the preference judgment trials, relative to visual discrimination trials. Other areas that were also differentially activated included the posterior parietal cortex, the anterior cingulate and the left anterior insula. These findings are consistent with the role of the ventromedial prefrontal cortex in the representation of complex appetitive states.
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Author information
Author/s: Paulus, Martin P (MP); Frank, Lawrence R (LR);
Affiliation: Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, CA 92093-0603, USA. martin(-atsign-)mag.ucsd.edu
Grants: R21DA13186 (Agency:United States NIDA)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Neuroreport (Neuroreport), published in England. (Language: eng)
Reference: 2003-Jul; vol 14 (issue 10) : pp 1311-5
Dates: Created 2003/07/23; Completed 2003/09/26; Revised 2007/11/14;
PMID: 12876463, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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