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Research article summary:
Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm.
Abstract Extract:
How do the frontal lobes support behavioural flexibility? One key element is the ability to adjust responses when the reinforcement value of stimuli change. In monkeys, this ability--a form of affective shifting known as reversal learning--depends on ... (Full abstract text below) Published 2003Aug
in Journal: Brain
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Brain.
2003 Aug;126(Pt 8):1830-7
Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm.
Fellows LK, Farah MJ
Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104-6196, USA. lesleyf@psych.upenn.edu
How do the frontal lobes support behavioural flexibility? One key element is the ability to adjust responses when the reinforcement value of stimuli change. In monkeys, this ability--a form of affective shifting known as reversal learning--depends on orbitofrontal cortex. The present study examines the anatomical bases of reversal learning in humans. Subjects with lesions of the ventromedial prefrontal cortex were compared with a group with dorsolateral frontal lobe damage, as well as with normal controls on a simple reversal learning task. Neither form of frontal damage affected initial stimulus-reinforcement learning; ventromedial frontal damage selectively impaired reversal learning.
PMID : 12821528 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Lesley K | Fellows | LK |
| Martha J | Farah | MJ |
Affiliation: Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104-6196, USA. lesleyf@psych.upenn.edu
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