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| Research article summary (published 18 Dec 2002): |
Variable effects of aging on frontal lobe contributions to memory.
Full Abstract
Declarative memory declines with age, but there is profound variation in the severity of this decline. Healthy elderly adults with high or low memory scores and young adults viewed words under semantic or non-semantic encoding conditions while undergoing fMRI. Young adults had superior memory for the words, and elderly adults with high memory scores had better memory for the words than those with low memory scores. The elderly with high scores had left lateral and medial prefrontal activations for semantic encoding equal to the young, and greater right prefrontal activation than the young. The elderly with low scores had reduced activations in all three regions relative to the elderly with high memory scores. Thus, successful aging was characterized by preserved left prefrontal and enhanced right prefrontal activation that may have provided compensatory encoding resources.
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Author information
Author/s: Rosen, Allyson C (AC); Prull, Matthew W (MW); O'Hara, Ruth (R); Race, Elizabeth A (EA); Desmond, John E (JE); Glover, Gary H (GH); Yesavage, Jerome A (JA); Gabrieli, John D E (JD);
Affiliation: Departments of Psychology, Jordan Hall, Bldg. 420, Stanford University, Stanford, CA 94305, USA.
Grants: 1F32 AG 05750 (Agency:United States NIA) ; 1F32 AG 05865-01 (Agency:United States NIA) ; AG 09466 (Agency:United States NIA) ; AG 12995 (Agency:United States NIA) ; MH 35182 (Agency:United States NIMH) ; MH 59940 (Agency:United States NIMH) ; RR 09784 (Agency:United States NCRR)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Neuroreport (Neuroreport), published in England. (Language: eng)
Reference: 2002-Dec; vol 13 (issue 18) : pp 2425-8
Dates: Created 2002/12/24; Completed 2003/04/04; Revised 2007/11/14;
PMID: 12499842, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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