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| Research article summary (published 27 Feb 2002): |
Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease.
Full Abstract
Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive methods is of great importance for clinical practice as effective and specific antidementive therapies become available. The aim of the study was to evaluate the clinical relevance of event-related P300 in the early diagnosis of AD. Thirty patients with AD, 26 patients with mild cognitive impairment (MCI) from our Memory Clinic and 26 age-matched healthy controls (HC) were studied with event-related P300 potentials. Amplitudes of temporo-basal dipoles (TB-P300) were significantly diminished in AD compared to HC and MCI. Furthermore, latencies of temporo-superior dipoles (TS-P300) were significantly prolonged in AD compared with HC. Sensitivity was 90.0% for the differentiation of patients with AD from HC (specificity 79.1%) using reduced TB-P300 amplitudes and prolonged TS-P300 latencies. Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD.
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Author information
Author/s: Frodl, Thomas (T); Hampel, Harald (H); Juckel, Georg (G); Bürger, Katharina (K); Padberg, Frank (F); Engel, Rolf R (RR); Möller, Hans-Jürgen (HJ); Hegerl, Ulrich (U);
Affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, Germany. tfrodlba(-atsign-)psy.med.uni-muenchen.de
Journal and publication information
Publication Type: Clinical Trial; Journal Article
Journal: Psychophysiology (Psychophysiology), published in United States. (Language: eng)
Reference: 2002-Mar; vol 39 (issue 2) : pp 175-81
Dates: Created 2002/09/05; Completed 2002/10/01; Revised 2004/11/17;
PMID: 12212666, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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