 |
| Research article summary (published 3 Jun 2003): |
Vacuole-creating protein in neurodegenerative diseases in humans.
Full Abstract
Vacuole-creating protein (VCP) is a member of the ATPases associated with diverse cellular activities and is a putative sensor protein for degenerative proteins. Immunohistochemical examinations demonstrated that VCP was observed in ubiquitin-positive intraneuronal inclusions in motor neuron disease with dementia, ballooned neurons in Creutzfeldt-Jakob disease, dystrophic neurites of senile plaque in Alzheimer's disease, and Lewy and Marinesco bodies and Lewy neurites in Parkinson's disease, while granules of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease were not positively stained for VCP. These results indicate that VCP reacts with abnormal or misfolded proteins and plays a role in accelerating the process of degeneration and cell death. The elucidation of an association between VCP and these degenerative proteins will provide an important clue for understanding common mechanisms underlying neurodegenerative diseases.
Learn Faster Today Improve your study skills
Author information
Author/s: Mizuno, Yuji (Y); Hori, Seiji (S); Kakizuka, Akira (A); Okamoto, Koichi (K);
Affiliation: Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. mizunoy(-atsign-)med.gunma-u.ac.jp
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)
Reference: 2003-Jun; vol 343 (issue 2) : pp 77-80
Dates: Created 2003/05/21; Completed 2003/08/07; Revised 2006/11/15;
PMID: 12759168, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.