Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study.

Full Abstract

The uncoupling protein 3 (UCP3) is a mitochondrial membrane transporter mainly expressed in skeletal muscle that we have shown to be associated with obesity. We have analyzed UCP3 polymorphisms, Val102Ile, Tyr210Tyr, and a new microsatellite GAIVS6 located in the sixth intron, among 276 black and 503 white subjects from the HERITAGE Family Study. Linkage and association studies were undertaken with body composition variables measured in a sedentary state (baseline) and after 20 wk of endurance training (changes). Allele and genotype frequencies were found to be significantly different between whites and blacks. Suggestive linkages (0.009 < or = P < or = 0.033) with Tyr210Tyr were found in blacks and whites for baseline body mass index, fat mass, or leptin level and with GAIVS6 in whites for changes in fat mass and percent body fat. Associations were also found in whites between GAIVS6 and changes in the sum of eight skinfold thicknesses (P = 0.0006), with a borderline result for body mass index (P = 0.06). We concluded that UCP3 could be involved in body composition changes after regular exercise.

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Author information

Author/s: Lanouette, Christian-Marc (CM); Chagnon, Yvon C (YC); Rice, Treva (T); Pérusse, Louis (L); Muzzin, Patrick (P); Giacobino, Jean-Paul (JP); Gagnon, Jacques (J); Wilmore, Jack H (JH); Leon, Arthur S (AS); Skinner, James S (JS); Rao, D C (DC); Bouchard, Claude (C);

Affiliation: Hôpital Laval and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte-Foy, Québec, Canada G1K 7P4.

Grants: 1P41RR03655 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol), published in United States. (Language: eng)

Reference: 2002-Mar; vol 92 (issue 3) : pp 1111-8

Dates: Created 2002/02/13; Completed 2002/05/07; Revised 2007/11/14;

PMID: 11842047, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
African Continental Ancestry Group - genetics
Alleles
Body Composition - physiology
Carrier Proteins - genetics
European Continental Ancestry Group - genetics
Female
Genotype
Humans

Associated Chemicals: Carrier Proteins (0) ; Ion Channels (0) ; Mitochondrial Proteins (0) ; mitochondrial uncoupling protein 3 (0)

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