Transient postictal magnetic resonance imaging abnormality of the corpus callosum in a patient with epilepsy. Case report and review of the literature.

Full Abstract

Transient neuroimaging abnormalities associated with seizure activity have received little attention in the literature. The authors report a focal magnetic resonance (MR) imaging abnormality of the corpus callosum in a patient following a secondary generalized seizure. A 27-year-old right-handed man presented with a history of medically refractory partial seizures since the age of 1 year. The results of an MR imaging study obtained 4 months prior to the patient undergoing video-electroencephalography monitoring were unremarkable. After the patient discontinued all antiepileptic medications, a secondary generalized seizure of right temporal origin was recorded. Five days later, repeated MR imaging revealed a nonenhancing 14 x 11-mm ovoid hyperintense lesion in the splenium of corpus callosum. The patient was asymptomatic, and his neurological and neurocognitive examinations remained unremarkable. Follow-up MR imaging 5 weeks and 1 year later demonstrated near-complete resolution of the lesion. Benign and transient abnormalities in the splenium can occur as a periictal phenomenon. A high index of suspicion and follow-up imaging may prevent further unwarranted intervention.

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Author information

Author/s: Cohen-Gadol, Aaron A (AA); Britton, Jeftrey W (JW); Jack, Clifford R (CR); Friedman, Jonathan A (JA); Marsh, W Richard (WR);

Affiliation: Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. cohengadol.aaron(-atsign-)mayo.edu

Journal and publication information

Publication Type: Case Reports; Journal Article; Review

Journal: Journal of neurosurgery (J Neurosurg), published in United States. (Language: eng)

Reference: 2002-Sep; vol 97 (issue 3) : pp 714-7

Dates: Created 2002/09/25; Completed 2002/10/11; Revised 2005/11/16;

PMID: 12296661, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Corpus Callosum - abnormalities; pathology; radionuclide imaging
Epilepsies, Partial - pathology; radionuclide imaging
Hippocampus - pathology; radionuclide imaging
Humans

Magnetic Resonance Imaging
Male
Temporal Lobe - pathology; radionuclide imaging
Time Factors
Tomography, Emission-Computed, Single-Photon

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