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| Research article summary (published 30 Oct 2002): |
Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study.
Full Abstract
The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation significantly increased in both delays the percentage of error in amplitude (PEA) of contralateral memory-guided saccades compared to the control experiment without stimulation. dTMS applied late in the delay had no significant effect on PEA. Furthermore, we found a significantly smaller effect of early stimulation in the long-delay paradigm. These results suggest a time-dependent hierarchical organization of the spatial working memory with a functional dominance of DLPFC during the early memorization, independent from the memorization delay. For a long memorization delay, however, working memory seems to have an additional, DLPFC-independent component.
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Author information
Author/s: Nyffeler, Thomas (T); Pierrot-Deseilligny, Charles (C); Felblinger, Jaques (J); Mosimann, Urs P (UP); Hess, Christian W (CW); Müri, René M (RM);
Affiliation: Eye Movement Research Laboratory, Department of Neurology, Bern University, Bern, CH-3010, Switzerland.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The European journal of neuroscience (Eur J Neurosci), published in France. (Language: eng)
Reference: 2002-Nov; vol 16 (issue 9) : pp 1823-7
Dates: Created 2002/11/14; Completed 2003/01/13; Revised 2006/11/15;
PMID: 12431236, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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