Theta oscillations in the hippocampus.

Full Abstract

Theta oscillations represent the "on-line" state of the hippocampus. The extracellular currents underlying theta waves are generated mainly by the entorhinal input, CA3 (Schaffer) collaterals, and voltage-dependent Ca(2+) currents in pyramidal cell dendrites. The rhythm is believed to be critical for temporal coding/decoding of active neuronal ensembles and the modification of synaptic weights. Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research.

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Author information

Author/s: Buzsáki, György (G);

Affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA. buzsaki(-atsign-)axon.rutgers.edu

Grants: MH54671 (Agency:United States NIMH) ; NS34994 (Agency:United States NINDS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2002-Jan; vol 33 (issue 3) : pp 325-40

Dates: Created 2002/02/08; Completed 2002/03/05; Revised 2007/11/14;

PMID: 11832222, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - physiology
Animals
Biological Clocks - physiology
Dentate Gyrus - physiology
Hippocampus - cytology; physiology
Humans

Models, Neurological
Neuronal Plasticity - physiology
Receptors, Cholinergic - metabolism
Receptors, GABA-A - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Theta Rhythm

Associated Chemicals: Receptors, Cholinergic (0) ; Receptors, GABA-A (0) ; Receptors, N-Methyl-D-Aspartate (0)

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