 |
| Research article summary (published 30 Oct 2002): |
A theory of cognitive control, aging cognition, and neuromodulation.
Full Abstract
A theory is described which links cognitive changes observed in normal aging to an underlying decline in the function of the dopamine (DA) system projection to prefrontal cortex (PFC). The theory postulates that this neural mechanism is integral to the representation, maintenance and updating of context information, and as such impacts cognitive control across a wide range of cognitive domains, including working memory, attention, and inhibition. Behavioral and brain imaging data in support of the theory are discussed, which demonstrate selective impairments in context processing among healthy older adults associated with abnormal PFC activation. These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined.
Learn Faster Today Improve your study skills
Author information
Author/s: Braver, Todd S (TS); Barch, Deanna M (DM);
Affiliation: Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA. tbraver(-atsign-)artsci.wustl.edu
Grants: AG18138 (Agency:United States NIA)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Neuroscience and biobehavioral reviews (Neurosci Biobehav Rev), published in United States. (Language: eng)
Reference: 2002-Nov; vol 26 (issue 7) : pp 809-17
Dates: Created 2002/12/09; Completed 2003/01/28; Revised 2007/11/14;
PMID: 12470692, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.