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| Research article summary (published 25 Aug 2002): |
Temporal lobectomy for epilepsy: recovery of the contralateral hippocampus measured by (1)H MRS.
Full Abstract
(1)H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p < 0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p < 0.02) and creatine-phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.
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Author information
Author/s: Vermathen, P (P); Ende, G (G); Laxer, K D (KD); Walker, J A (JA); Knowlton, R C (RC); Barbaro, N M (NM); Matson, G B (GB); Weiner, M W (MW);
Affiliation: MR Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA.
Grants: R01-NS31966 (Agency:United States NINDS)
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neurology (Neurology), published in United States. (Language: eng)
Reference: 2002-Aug; vol 59 (issue 4) : pp 633-6
Dates: Created 2002/08/28; Completed 2002/09/20; Revised 2007/11/14;
PMID: 12196667, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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