 |
| Research article summary (published 29 Apr 2003): |
Sustained and transient activity during an object-naming task: a mixed blocked and event-related fMRI study.
Full Abstract
Cognitive tasks often involve at least two types of processes-sustained processes potentially related to ongoing task demands and transient processes related to the processing of individual items within the task. Using functional magnetic resonance imaging, in conjunction with a mixed-blocked and event-related design, we examined sustained and transient patterns of neural activity during an object-naming task. Subjects were imaged during runs that alternated between control blocks and task blocks. During task blocks, primed and unprimed objects were intermixed and jittered in time. Regions of interest based on separate analyses of sustained and transient activities were tested independently for sustained and transient responses. Three general patterns of results were observed. (1) Some regions exhibited transient responses but little or no sustained response. These regions were widely distributed across the brain. (2) Other regions clearly exhibited both transient and sustained responses. These regions were found primarily in lateral and medial frontal lobes. (3) A few regions exhibited a sustained response but little or no transient responses. These regions were found in the basal ganglia, orbitofrontal lobe, and right lateral frontal lobe. Furthermore, two homotopic regional pairs in the right and left inferior frontal lobe (frontal operculum and inferior frontal cortex) showed a crossover of sustained and transient effects, with greater transient activity in the left and greater sustained activity in the right hemisphere. The asymmetric relationship between sustained and transient responses in prefrontal regions may be an example of task-specific biasing at work.
Learn Faster Today Improve your study skills
Author information
Author/s: Burgund, E Darcy (ED); Lugar, Heather M (HM); Miezin, Francis M (FM); Petersen, Steven E (SE);
Affiliation: Department of Neurology, Washington University, St. Louis, MO 63110, USA. darcy@npg.wustl.edu
Grants: LM06858 (Agency:United States NLM) ; NS32979 (Agency:United States NINDS) ; NS51733 (Agency:United States NINDS)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-May; vol 19 (issue 1) : pp 29-41
Dates: Created 2003/06/03; Completed 2003/07/21; Revised 2007/11/14;
PMID: 12781725, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.