 |
| Research article summary (published 29 Nov 2002): |
|
Free Full Text! See links below |
Suppression of false recognition in Alzheimer's disease and in patients with frontal lobe lesions.
Full Abstract
Previous research has shown that patients with Alzheimer's disease show increasing levels of false recognition across five repeated study-test trials of semantic associates. The present study tested the hypotheses that (i) the increasing false recognition was partly due to the frontal lobe dysfunction of patients with Alzheimer's disease, and (ii) a failure of source monitoring was the central mechanism by which frontal lobe dysfunction led to increasing false recognition across trials. In Experiment 1, patients with frontal lobe lesions and controls were examined in the same repeated trials paradigm as that used previously in patients with Alzheimer's disease. Although controls were able to reduce their false recognition across trials, the patients with frontal lobe lesions were not, and instead showed a constant level of elevated false recognition across the study-test trials. In Experiment 2, two groups of patients with Alzheimer's disease and healthy older adult controls were studied:
the first group was given a single study session followed by a recognition test, the second group was given five study sessions followed by a single recognition test. Older adults who were exposed to five study lists demonstrated lower levels of false relative to true recognition, whereas patients with Alzheimer's disease in this condition exhibited levels of false recognition elevated to that of their true recognition, even with the source memory confusion of intervening tests eliminated. The authors suggest that impairment in aspects of frontal lobe function, such as verification-inhibition mechanisms, probably contributes to the inability of patients with Alzheimer's disease to suppress their false recognition across repeated trials. Lastly, it is speculated that one way in which the frontal lobes enable normal episodic memory function is by facilitating the suppression of false recognition and other distortions of memory.
Learn Faster Today Improve your study skills
Author information
Author/s: Budson, A E (AE); Sullivan, A L (AL); Mayer, E (E); Daffner, K R (KR); Black, P M (PM); Schacter, D L (DL);
Affiliation: Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. abudson@partners.org
Grants: AG08441 (Agency:United States NIA) ; F32 MH11767 (Agency:United States NIMH) ; K23 MH01870 (Agency:United States NIMH) ; NS26980 (Agency:United States NINDS)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Brain : a journal of neurology (Brain), published in England. (Language: eng)
Reference: 2002-Dec; vol 125 (issue Pt 12) : pp 2750-65
Dates: Created 2002/11/13; Completed 2002/12/31; Revised 2007/11/14;
PMID: 12429602, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.