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| Research article summary (published 30 Mar 2003): |
A subsequent-memory effect in dorsolateral prefrontal cortex.
Full Abstract
The importance of brain regions for long-term memory encoding has been examined by comparison of encoding-related neural activity on trials in which successful recollection subsequently occurred to the encoding-related activity on trials in which successful recollection did not occur. We applied similar analyses to event-related functional magnetic resonance imaging (fMRI) data to explore the relative roles of dorsolateral and ventrolateral prefrontal cortex (PFC) regions during specific components of a working-memory (WM) maintenance task. The results of this study indicated that increases in dorsolateral PFC activity during encoding was related to subsequent retrieval-success. These results lend support to the hypothesis that ventrolateral PFC mediates a limited-capacity WM buffer that supports rehearsal maintenance functions while dorsolateral PFC mediates WM organization functions that accommodate the capacity limits of WM maintenance.
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Author information
Author/s: Rypma, Bart (B); D'Esposito, Mark (M);
Affiliation: Department of Psychology, Rutgers University, Smith Hall, 101 Warren Street, Newark, NJ 07102, USA. rypma@psychology.rutgers.edu
Journal and publication information
Publication Type: Clinical Trial; Journal Article
Journal: Brain research. Cognitive brain research (Brain Res Cogn Brain Res), published in Netherlands. (Language: eng)
Reference: 2003-Apr; vol 16 (issue 2) : pp 162-6
Dates: Created 2003/04/01; Completed 2003/05/29; Revised 2006/11/15;
PMID: 12668223, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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