 |
| Research article summary (published 30 Jul 2002): |
A study of transcallosal inhibition in schizophrenia using transcranial magnetic stimulation.
Full Abstract
A considerable body of imaging research has demonstrated morphological changes in the corpus callosum (CC) of patients with schizophrenia. Transcranial magnetic stimulation (TMS) allows the possibility for the in vivo investigation of a variety of aspects of brain function including the spread of information across the CC. We aimed to investigate whether patients with schizophrenia demonstrate abnormalities of transcallosal inhibition (TCI), a TMS parameter measured with both single and paired pulse experiments. 25 patients with DSM-IV schizophrenia and 20 normal volunteers participated in the study. Electromyographic (EMG) recordings from the bilateral abductor pollicis brevis (APB) muscle were made during focal TMS stimulation to the motor cortex. Experimental paradigms were utilised to measure both the timing and degree of the effect of TCI. The patient group demonstrated a reduction in the degree of TCI at rest and during a sustained muscle contraction. TCI commenced at the same time in the patient and the control group but was of prolonged duration in the patient group although the length of TCI correlated with medication dose. Patients with schizophrenia demonstrate a reduction in the degree of TCI that appeared independent of medication dose. The latency of TCI is not altered in the patient group suggesting that cortical inhibitory mechanisms, rather than corpus callosal ones, are likely to be the cause of these TCI alterations.
Learn Faster Today Improve your study skills
Author information
Author/s: Fitzgerald, P B (PB); Brown, T L (TL); Daskalakis, Z J (ZJ); deCastella, A (A); Kulkarni, J (J);
Affiliation: Dandenong Psychiatry Research Centre, Monash University and Dandenong Area Mental Health Service, P.O. Box 956, Dandenong, Vic. 3175, Australia. pbfitz@ozemail.com.au
Journal and publication information
Publication Type: Evaluation Studies; Journal Article
Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)
Reference: 2002-Aug; vol 56 (issue 3) : pp 199-209
Dates: Created 2002/06/19; Completed 2002/07/30; Revised 2005/11/17;
PMID: 12072169, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.