Research article summary:

The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study.

Abstract Extract:
Schizotypal personality features and certain neurocognitive deficits have been shown to aggregate in the relatives of schizophrenic patients, supporting the view that both are likely to reflect genetic contributions to liability to schizophrenia. Within ... (Full abstract text below)

Published 2002Mar in Journal: Schizophr Res (Language : eng)

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1. Schizophr Res. 2002 Mar;54(1-2):121-30

The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study.

Nuechterlein KH, Asarnow RF, Subotnik KL, Fogelson DL, Payne DL, Kendler KS, Neale MC, Jacobson KC, Mintz J

UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2240, Los Angeles, CA 90095-6968, USA. keithn@ucla.edu

Schizotypal personality features and certain neurocognitive deficits have been shown to aggregate in the relatives of schizophrenic patients, supporting the view that both are likely to reflect genetic contributions to liability to schizophrenia. Within the relatives of schizophrenic patients, however, the interrelationships between these potential indicators of liability to schizophrenia are not well known. Using data from the UCLA Family Study, we examine the interrelationships between personality disorder symptoms and neurocognitive functioning in nonpsychotic first-degree relatives of schizophrenic patients. Factor analyses indicate that several dimensions of schizotypy can be identified. A neurocognitive dysfunction dimension includes loadings from measures of sequential visual conceptual tracking, rapid perceptual encoding and search, and focused, sustained attention as well as the rating of odd and eccentric behavior from schizotypal personality disorder. Other aspects of schizotypal personality disorder form separate positive schizotypy and negative schizotypy dimensions. These analyses support the view that schizotypy is multidimensional in relatives of schizophrenic patients and indicate that neurocognitive deficits in perception and attention are associated with particular schizotypal personality features.

PMID : 11853986 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Keith H	Nuechterlein	KH
Robert F	Asarnow	RF
Kenneth L	Subotnik	KL
David L	Fogelson	DL
Diana L	Payne	DL
Kenneth S	Kendler	KS
Michael C	Neale	MC
Kristen C	Jacobson	KC
Jim	Mintz	J

Affiliation: UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2240, Los Angeles, CA 90095-6968, USA. keithn@ucla.edu

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