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Research article summary:
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimers disease.
Abstract Extract:
Recent stereological studies documented a severe loss of hippocampal neurons in end-stage Alzheimers disease. The development of the disease, however, is progressive and slow, over clinically inconspicuous decades. The Braak-staging system distinguishes ... (Full abstract text below) Published 2002Apr
in Journal: Acta Neuropathol
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Acta Neuropathol.
2002 Apr;103(4):363-9
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease.
Rössler M, Zarski R, Bohl J, Ohm TG
Universitätsklinikum Charité, Institut für Anatomie, Philippstrasse 12, 10098 Berlin, Germany.
Recent stereological studies documented a severe loss of hippocampal neurons in end-stage Alzheimer's disease. The development of the disease, however, is progressive and slow, over clinically inconspicuous decades. The Braak-staging system distinguishes six histopathological stages some of which are not accompanied by clinical symptoms. We analyzed hippocampal cell loss in correlation to Braak stages. Neuron numbers were determined with unbiased stereological principles in a defined subportion of the hippocampus of 28 subjects. There were no age-dependent neuronal losses in any of the hippocampal subdivisions examined. Compared to stage I, pyramidal cell loss in CA1 was reduced by 33% in stage IV ( P<0.02) and by 51% in stage V ( P<0.0002). In the subiculum, considerable neuron loss was seen only in stage V (22%; P<0.09). Other subdivisions of the Ammon's horn showed no neuron loss. Neuron loss was greater than volume loss, e.g., neuron loss of 51% between stages I and V in CA1 was accompanied by volume loss of only 25%. Our findings indicate (i) that neuronal loss is sector and stage dependent, (ii) that neuronal loss in CA1 and the subiculum is related to the formation of neurofibrillary tangles, and (iii) that neuron loss makes a weak contribution to the observed volume loss.
PMID : 11904756 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Marcus | Rössler | M |
| Rosemarie | Zarski | R |
| Jürgen | Bohl | J |
| Thomas G | Ohm | TG |
Affiliation: Universitätsklinikum Charité, Institut für Anatomie, Philippstrasse 12, 10098 Berlin, Germany.
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MESH categories and related page links
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Category links from this article:- Aged
- Aged, 80 and over
- Alzheimer Disease - pathology
- Cell Count
- Female
- Hippocampus - pathology
- Humans
- Male
- Middle Aged
- Neurons - pathology
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