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| Research article summary (published 29 Nov 2002): |
Spatial working memory in human extrastriate cortex.
Full Abstract
The performance of spatial working memory tasks is known to evoke activity in a set of higher-order association areas, including the prefrontal cortex, posterior parietal cortex and the frontal and supplementary eye fields. Recent physiological studies in monkey have shown that memory-related activity also is found in extrastriate cortex [J. Neurophysiol. 84 (2000) 677]. We conducted functional magnetic resonance imaging studies to determine whether human extrastriate cortex contributes to the on-line maintenance of spatial information in an eye movement task. We found that performance of memory-guided saccades, as compared to visually guided saccades, elicited significant activation in two areas of extrastriate cortex:
the posterior superior temporal sulcus (PST) and lateral occipitotemporal cortex (LOT). Both areas also were activated during the basic sensorimotor task of visually guided saccades as compared to fixation. We further determined that area LOT is close to but distinct from motion-sensitive area MT+. These findings demonstrate that areas PST and LOT, along with higher-level association cortex, help to encode and maintain spatial representations.
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Author information
Author/s: Berman, Rebecca A (RA); Colby, Carol L (CL);
Affiliation: Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA.
Journal and publication information
Publication Type: Clinical Trial; Journal Article
Journal: Physiology & behavior (Physiol Behav), published in United States. (Language: eng)
Reference: 2002-Dec; vol 77 (issue 4-5) : pp 621-7
Dates: Created 2003/01/15; Completed 2003/07/11; Revised 2004/11/17;
PMID: 12527009, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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