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| Research article summary (published 30 May 2003): |
Slowing of electroencephalogram in rapid eye movement sleep behavior disorder.
Full Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by a loss of atonia and an increase in phasic muscle activity during REM sleep, leading to complex nocturnal motor behaviors. Brainstem structures responsible for the pathogenesis of RBD are also implicated in cortical activation. To verify the hypothesis that electroencephalogram (EEG) activation will be impaired in RBD, we performed quantitative analyses of waking and REM sleep EEG in 15 idiopathic RBD patients and 15 age- and gender-matched healthy subjects. During wakefulness, RBD patients showed a considerably higher theta power in frontal, temporal, and occipital regions with a lower beta power in the occipital region. The dominant occipital frequency was significantly lower in RBD. During REM sleep, beta power in the occipital region was lower in RBD. This study shows for the first time an impaired cortical activation during both wakefulness and REM sleep in idiopathic RBD, despite an absence of changes on sleep architecture compared with controls. EEG slowing in these patients may represent an early sign of central nervous system dysfunction, perhaps paralleled by subclinical cognitive deficits. The topographical distribution of EEG slowing and possible pathophysiological mechanisms are discussed in light of the known association between RBD and neurodegenerative disorders.
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Author information
Author/s: Fantini, Maria Livia (ML); Gagnon, Jean-François (JF); Petit, Dominique (D); Rompré, Sylvie (S); Décary, Anne (A); Carrier, Julie (J); Montplaisir, Jacques (J);
Affiliation: Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur, Québec, Canada.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2003-Jun; vol 53 (issue 6) : pp 774-80
Dates: Created 2003/06/03; Completed 2003/07/09; Revised 2006/11/15;
PMID: 12783424, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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