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| Research article summary (published 26 May 2002): |
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Single-neuron correlates of subjective vision in the human medial temporal lobe.
Full Abstract
Visual information from the environment is transformed into perceptual sensations through several stages of neuronal processing. Flash suppression constitutes a striking example in which the same retinal input can give rise to two different conscious visual percepts. We directly recorded the responses of individual neurons during flash suppression in the human amygdala, entorhinal cortex, hippocampus, and parahippocampal gyrus, allowing us to explore the neuronal responses in untrained subjects at a high spatial and temporal resolution in the medial temporal lobe. Subjects were patients with pharmacologically intractable epilepsy implanted with depth electrodes to localize the seizure onset focus. We observed that the activity of two thirds of all visually selective neurons followed the perceptual alternations rather than the retinal input. None of the selective neurons responded to a perceptually suppressed stimulus. Therefore, the activity of most individual neurons in the medial temporal lobe of naive human subjects directly correlates with the phenomenal visual experience.
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Author information
Author/s: Kreiman, Gabriel (G); Fried, Itzhak (I); Koch, Christof (C);
Affiliation: Computation and Neural Systems Program, California Institute of Technology 139-74, Pasadena, CA 91125, USA. gabriel(-atsign-)klab.caltech.edu
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), published in United States. (Language: eng)
Reference: 2002-Jun; vol 99 (issue 12) : pp 8378-83
Dates: Created 2002/06/12; Completed 2002/08/02; Revised 2006/11/15;
PMID: 12034865, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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