Research article summary:

Single-cue delay and trace classical conditioning in schizophrenia.

Abstract Extract:
BACKGROUND: Classical conditioning provides a means of addressing mechanisms of learning and can therefore help understand the pathophysiology of memory alteration in schizophrenia. METHODS: Single cue delay and trace eyeblink conditioning were used in ... (Full abstract text below)

Published 2003Mar in Journal: Biol Psychiatry (Language : eng)

Full Pubmed Extract

This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:

1. Biol Psychiatry. 2003 Mar;53(5):390-402

Single-cue delay and trace classical conditioning in schizophrenia.

Marenco S, Weinberger DR, Schreurs BG

Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

BACKGROUND: Classical conditioning provides a means of addressing mechanisms of learning and can therefore help understand the pathophysiology of memory alteration in schizophrenia. METHODS: Single cue delay and trace eyeblink conditioning were used in patients with schizophrenia and matched normal control subjects to explore, respectively, cerebellar and hippocampal integrity during learning. We measured percent of conditioned (CRs) and unconditioned responses (URs), their amplitude, and onset and peak latencies. We also accounted for spontaneous blink rates and stimulus-induced responses before learning. RESULTS: During delay conditioning, patients showed CRs with longer onset and peak latencies and improved efficiency compared to normal volunteers without there being differences between patients and normal control subjects in the percentage of CRs. During trace conditioning, neither group showed an increase in CRs as a function of conditioned stimulus-unconditioned stimulus pairings, in part because the level of spontaneous blink rates exceeded the level of CRs; however, patients with schizophrenia showed increased responding 150-400 msec after the conditioned stimulus and in the last 100-150 msec before the unconditioned stimulus, whereas normal control subjects showed only the latter type of responses. The former type of response was more frequent in patients with schizophrenia even before either trace or delay conditioning. CONCLUSIONS: These results suggest integrity of cerebellar mechanisms underlying conditioning, although the altered timing of CRs in patients may indicate differences in the modulation of such responses. Both the greater CR onset latency during delay and the presence of early nonadaptive responses during trace are compatible with the pattern of responding seen in animals with hippocampal damage.

PMID : 12614992 [PubMed - Indexed for MEDLINE]

This information is obtained from the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright. Type "NLM copyright" into Google for more information.

Full Author Information

First Name	LastName	Initials
Stefano	Marenco	S
Daniel R	Weinberger	DR
Bernard G	Schreurs	BG

Affiliation: Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

3rd Party provider links

Click the links below to go to related 3rd party information:

MESH categories and related page links

This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.

Links for this article

For links to places where you can get the full text of this article see links. Note there may be a subscription or fee required for access to the full text.

New! Using similar technology to this site, we have launched find-health-articles.com, targeting over 1 million health research article abstracts.

Here are some articles related to this one (by title keywords):

Latency correction explains the classical geometrical illusions.

Excitability changes in human corticospinal projections to forearm muscles during voluntary movement of ipsilateral foot.

Ecological statistics of Gestalt laws for the perceptual organization of contours.

Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies.

Assessing the effect of posture change on tactile inhibition-of-return.

Appetitive and aversive olfactory learning in humans studied using event-related functional magnetic resonance imaging.

Activity-dependent development of axonal and dendritic delays, or, why synaptic transmission should be unreliable.

Practice effects on two memory retrievals from a single cue.

Neural correlates of successful encoding identified using functional magnetic resonance imaging.

Multiple response measures during classical conditioning.

>>> Get more research article abstracts like these, or browse abstracts.

Keywords in this article:

accounted, addressing, after, alteration, altered, amplitude, animals, background, cerebellar, classical, compared, compatible, conclusions, conditioned, conditioning, control, crs, cue, delay, differences, early, efficiency, even, exceeded, explore, eyeblink, former, frequent, function, greater, group, help, hippocampal, improved, increase, increased, indicate, induced, integrity, last, latencies, latency, latter, learning, level, longer, matched, means, measured, mechanisms, memory, methods, modulation, more, msec, nonadaptive, normal, only, onset, pairings, part, pathophysiology, patients, pattern, peak, percent, percentage, presence, provides, rates, respectively, responding, responses, results, schizophrenia, single, spontaneous, stimulus, subjects, suggest, timing, trace, type, unconditioned, underlying, understand, urs, volunteers, whereas

Also, see our new free speed reading online course (beta version)