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| Research article summary (published 30 Jul 2003): |
Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm.
Full Abstract
Infrequent occurrences of a deviant sound within a sequence of repetitive standard sounds elicit the automatic mismatch negativity (MMN) event-related potential (ERP). The main MMN generators are located in the superior temporal cortex, but their number, precise location, and temporal sequence of activation remain unclear. In this study, ERP and functional magnetic resonance imaging (fMRI) data were obtained simultaneously during a passive frequency oddball paradigm. There were three conditions, a STANDARD, a SMALL deviant, and a LARGE deviant. A clustered image acquisition technique was applied to prevent contamination of the fMRI data by the acoustic noise of the scanner and to limit contamination of the electroencephalogram (EEG) by the gradient-switching artifact. The ERP data were used to identify areas in which the blood oxygenation (BOLD) signal varied with the magnitude of the negativity in each condition. A significant ERP MMN was obtained, with larger peaks to LARGE deviants and with frontocentral scalp distribution, consistent with the MMN reported outside the magnetic field. This result validates the experimental procedures for simultaneous ERP/fMRI of the auditory cortex. Main foci of increased BOLD signal were observed in the right superior temporal gyrus [STG; Brodmann area (BA) 22] and right superior temporal plane (STP; BA 41 and 42). The imaging results provide new information supporting the idea that generators in the right lateral aspect of the STG are implicated in processes of frequency deviant detection, in addition to generators in the right and left STP.
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Author information
Author/s: Liebenthal, Einat (E); Ellingson, Michael L (ML); Spanaki, Marianna V (MV); Prieto, Thomas E (TE); Ropella, Kristina M (KM); Binder, Jeffrey R (JR);
Affiliation: Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. einatl(-atsign-)mcw.edu
Grants: R01 NS 33576 (Agency:United States NINDS) ; R21 DC 04880 (Agency:United States NIDCD)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Aug; vol 19 (issue 4) : pp 1395-404
Dates: Created 2003/09/01; Completed 2003/10/23; Revised 2007/11/14;
PMID: 12948697, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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