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| Research article summary (published 29 Apr 2002): |
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Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.
Full Abstract
OBJECTIVE:
The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.
METHOD:
Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects.
RESULTS:
No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder.
CONCLUSIONS:
Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.
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Author information
Author/s: Frumin, Melissa (M); Golland, Polina (P); Kikinis, Ron (R); Hirayasu, Yoshio (Y); Salisbury, Dean F (DF); Hennen, John (J); Dickey, Chandlee C (CC); Anderson, Mark (M); Jolesz, Ferenc A (FA); Grimson, W Eric L (WE); McCarley, Robert W (RW); Shenton, Martha E (ME);
Affiliation: Consolidated Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System-Brockton Division, 02301, USA.
Grants: MH-01110 (Agency:United States NIMH) ; MH-40799 (Agency:United States NIMH) ; MH-50740 (Agency:United States NIMH) ; P41-RR-1321 (Agency:United States NCRR) ; R01-RR-11747 (Agency:United States NCRR)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)
Reference: 2002-May; vol 159 (issue 5) : pp 866-8
Dates: Created 2002/05/02; Completed 2002/06/03; Revised 2007/11/14;
PMID: 11986146, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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