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| Research article summary (published 11 Jul 2002): |
Sex differences in the subjective and reinforcing effects of cigarette nicotine dose.
Full Abstract
RATIONALE:
Some research with novel nicotine delivery methods suggests that nicotine itself may be less reinforcing in women than in men. However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention.
OBJECTIVES:
Sex differences in the subjective and reinforcing effects of smoking were examined as a function of two cigarette nicotine "dose" levels (moderate - subjects' preferred brand, > or = 0.7 mg yield; low - Carlton "ultra-light", 0.1 mg yield).
METHODS:
Male and female smokers ( n = 30) participated in three sessions, the first two involving independent assessment (only one brand available), and the third involving concurrent assessment (both brands available), of subjective ratings (e.g. "liking") and reinforcement for the two cigarette brands. Subjects were blind to the brand of each cigarette, and subjects abstained overnight prior to each session. Reinforcement was determined by responses on a computer task to earn single puffs on the designated cigarette.
RESULTS:
Subjective ratings differed between the low versus moderate cigarette nicotine dose under both independent and concurrent assessment conditions, as expected. Notably, this dose difference was smaller in women than in men (i.e. significant sex by dose interactions). The dose effect on smoke reinforcement also was smaller in women than men, but only under the independent and not concurrent assessment condition.
CONCLUSIONS:
These results indicate that cigarette nicotine dose is a less important influence on the subjective and, under some conditions, reinforcing effects of smoking in women than in men.
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Author information
Author/s: Perkins, Kenneth A (KA); Jacobs, Lynette (L); Sanders, Mark (M); Caggiula, Anthony R (AR);
Affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. perkinska@msx.upmc.edu
Grants: DA12655 (Agency:United States NIDA)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Psychopharmacology (Psychopharmacology (Berl)), published in Germany. (Language: eng)
Reference: 2002-Sep; vol 163 (issue 2) : pp 194-201
Dates: Created 2002/08/30; Completed 2003/03/03; Revised 2007/11/14;
PMID: 12202966, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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