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Research article summary (published 30 Aug 2002):

Serum levels of coenzyme Q in patients with Lewy body disease.

Full Abstract

The purpose of the present study was to compare serum levels of coenzyme Q(10) (CoQ(10)) and the coenzyme Q(10) cholesterol (CoQ(10)/cholesterol) ratio in 18 patients with Lewy body disease (LBD) with 20 matched controls. The mean serum coenzyme Q10 levels in patients with LBD were significantly reduced with respect to control group, however, no differences were found in CoQ(10)/cholesterol ratio between LBD patients and control group. There was no correlation among CoQ(10) and CoQ(10)/cholesterol ratio with age, age of onset, body mass index, duration of the disease or scores of the Mini Mental State Examination, UPDRS and Hoehn and Yahr stage. These results suggest the involvement of this enzimatic system in the pathogenic mechanism of LBD.

 

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Author information

Author/s: Molina, J A (JA); de Bustos, F (F); Ortiz, S (S); Del Ser, T (T); Seijo, M (M); Benito-Léon, J (J); Oliva, J M (JM); Pérez, S (S); Manzanares, J (J);

Affiliation: Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, Spain.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm), published in Austria. (Language: eng)

Reference: 2002-Sep; vol 109 (issue 9) : pp 1195-201

Dates: Created 2002/08/30; Completed 2002/11/06; Revised 2007/11/15;

PMID: 12203046, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Associated Chemicals: Coenzymes (0) ; Cytochrome c Group (0) ; Nerve Tissue Proteins (0) ; Synucleins (0) ; Ubiquinone (1339-63-5) ; coenzyme Q10 (303-98-0) ; Cholesterol (57-88-5)

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