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| Research article summary (published 30 Dec 2002): |
Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.
Full Abstract
The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population.Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up. Serum concentrations of different sterols related to cholesterol were measured.Serum levels of lathosterol and lanosterol correlated negatively with cognitive performance on the Word Learning tests for verbal learning and memory. This was observed at baseline and follow-up and was independent of age, sex and educational level. Furthermore, the levels of lathosterol and lanosterol at baseline correlated with performance on the Stroop test and Word Learning tests over the 6-year follow-up period. Serum levels of 27-hydroxycholesterol and 24S-hydroxycholesterol showed inconsistent correlations, while cholesterol, desmosterol, sitosterol and campesterol were not related to cognitive performance.Thus, relative high serum ratios of the cholesterol precursors lanosterol and lathosterol, indicative for a high rate of endogenous cholesterol synthesis, are associated with relatively low memory performance in this aging population.
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Author information
Author/s: Teunissen, C E (CE); De Vente, J (J); von Bergmann, K (K); Bosma, H (H); van Boxtel, M P J (MP); De Bruijn, C (C); Jolles, J (J); Steinbusch, H W M (HW); Lütjohann, D (D);
Affiliation: European Graduate School of Neuroscience (Euron), Universiteit Maastricht, Maastricht, The Netherlands. c.teunissen.cell@med.vu.nl
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Neurobiology of aging (Neurobiol Aging), published in United States. (Language: eng)
Reference: -2003 Jan-Feb; vol 24 (issue 1) : pp 147-55
Dates: Created 2002/12/20; Completed 2003/03/26; Revised 2006/11/15;
PMID: 12493560, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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