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| Research article summary (published 27 Feb 2002): |
Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study.
Full Abstract
We used fMRI to examine patterns of brain recruitment in 22 healthy seniors, half of whom had selective comprehension difficulty for grammatically complex sentences. We found significantly reduced recruitment of left posterolateral temporal [Brodmann area (BA) 22/21] and left inferior frontal (BA 44/6) cortex in poor comprehenders compared to the healthy seniors with good sentence comprehension, cortical regions previously associated with language comprehension and verbal working memory, respectively. The poor comprehenders demonstrated increased activation of left prefrontal (BA 9/46), right dorsal inferior frontal (BA 44/6), and left posterior cingulate (BA 31/23) cortices for the grammatically simpler sentences that they understood. We hypothesize that these brain regions support an alternate, nongrammatical strategy for processing complex configurations of symbolic information. Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension.Copyright 2002 Elsevier Science (USA).
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Author information
Author/s: Grossman, Murray (M); Cooke, Ayanna (A); DeVita, Chris (C); Chen, Willis (W); Moore, Peachie (P); Detre, John (J); Alsop, David (D); Gee, James (J);
Affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, USA. mgrossma@mail.med.upenn.edu
Grants: AG15116 (Agency:United States NIA) ; AG17586 (Agency:United States NIA) ; NS35867 (Agency:United States NINDS)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Brain and language (Brain Lang), published in United States. (Language: eng)
Reference: 2002-Mar; vol 80 (issue 3) : pp 296-313
Dates: Created 2002/03/18; Completed 2002/05/21; Revised 2007/11/14;
PMID: 11896643, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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