Semantic and cross-case identity priming in patients with Parkinson's disease.

Full Abstract

Semantic and cross-case identity priming were investigated in nondemented patients with Parkinson's disease (PD) and controls using the Lexical Decision Task. Three conditions were administered that consisted of the presentation of prime and target word pairs. In the semantic priming condition the word pairs were semantically related (e.g., table-CHAIR), in the cross-case identity priming condition the word pairs consisted of the same word (e.g., noise-NOISE), and in the unrelated condition the word pairs were not related semantically (e.g., guns-DEEP). A fourth condition was also administered that consisted of the presentation of a prime word and a pronounceable nonword target (e.g., starved-FORVE). Participants were asked to indicate whether the target was a real word or a nonword. The prime and target were separated by either a short or long (250 ms or 1000 ms) stimulus onset asynchrony (SOA). Results indicated that PD patients displayed normal semantic priming (i.e., faster responding to the target in the semantic condition as compared to the unrelated condition) at both the short and long SOA. Similarly, PD patients displayed normal cross-case identity priming (i.e., faster responding to the target in the identity condition relative to the unrelated condition) at the long SOA. At the short SOA, however, PD patients displayed hyper identity priming relative to controls (134 ms vs. 50 ms). These results suggest that semantic processes are normal in nondemented PD patients but that the processes involved in accessing lexical information may be overly activated in these patients.

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Author information

Author/s: Filoteo, J Vincent (JV); Friedrich, Frances J (FJ); Rilling, Laurie M (LM); Davis, Jennifer D (JD); Stricker, John L (JL); Prenovitz, Mark (M);

Affiliation: University of California, Veterans Administration San Diego Healthcare System, San Diego, CA, USA. vfiloteo@ucsd.edu

Grants: NS41372 (Agency:United States NINDS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Journal of clinical and experimental neuropsychology (J Clin Exp Neuropsychol), published in Netherlands. (Language: eng)

Reference: 2003-Jun; vol 25 (issue 4) : pp 441-56

Dates: Created 2003/08/12; Completed 2003/09/17; Revised 2008/04/14;

PMID: 12911099, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Male
Middle Aged
Neuropsychological Tests - statistics & numerical data
Paired-Associate Learning
Parkinsonian Disorders - physiopathology
Reaction Time
Semantics
Word Association Tests

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