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| Research article summary (published 30 May 2003): |
Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.
Full Abstract
Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental memory for emotional stimuli were assessed in 20 healthy volunteers (10 female). Triazolam reduced the normally facilitative effect of emotion on memory. The drug specifically affected memory for the gist of stimuli while leaving detail memory relatively unaffected. This pattern of performance is similar to that seen in patients with amygdala damage. Results suggest an effect of GABAergic neurotransmission at the level of the amygdala on memory modulation.
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Author information
Author/s: Buchanan, Tony W (TW); Karafin, Matthew S (MS); Adolphs, Ralph (R);
Affiliation: Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA. tonybuchanan@uiowa.edu
Grants: MH57905 (Agency:United States NIMH) ; P01 NS19632 (Agency:United States NINDS) ; T32 AG00214 (Agency:United States NIA)
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)
Reference: 2003-Jun; vol 117 (issue 3) : pp 517-25
Dates: Created 2003/06/13; Completed 2003/08/04; Revised 2007/11/14;
PMID: 12802880, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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