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| Research article summary (published 30 Oct 2002): |
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Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making.
Full Abstract
Decision-making is a complex process that is important for everyday life. This study examined the effect of the degree of success, and outcome uncertainty, on decision-making and associated neural substrate activation in schizophrenia subjects (SZS) and normal comparison subjects (NCS). A total of 15 subjects with a diagnosis of schizophrenia and 15 age- and education-matched NCS participated in this study. These subjects completed the two-choice prediction task during functional magnetic resonance imaging. Decision-making characteristics and activation of neural substrates were obtained at 20, 50, or 80% error rate. Success and uncertainty influenced the behavioral characteristics on the two-choice prediction task, and the task-related activation in SZS and NCS. Neither success nor uncertainty differentially affected the behavioral characteristics of SZS relative to NCS during the two-choice prediction task. Nonetheless, there was a significant interaction between group and error rate in bilateral parietal cortex. The activation in NCS was the highest when the outcome was most uncertain. In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes.
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Author information
Author/s: Paulus, Martin P (MP); Frank, Lawrence (L); Brown, Gregory G (GG); Braff, David L (DL);
Affiliation: Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, CA, USA. martin(-atsign-)mag.ucsd.edu
Grants: MH R37-42228 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology), published in United States. (Language: eng)
Reference: 2003-Apr; vol 28 (issue 4) : pp 795-806
Dates: Created 2003/03/25; Completed 2003/05/29; Revised 2007/11/14;
PMID: 12655327, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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