 |
| Research article summary (published 30 Jan 2003): |
Satellite cells and training in the elderly.
Full Abstract
In the present review, we describe the effects of ageing on human muscle fibres, underlining that each human muscle is unique, meaning that the phenotype becomes specifically changed upon ageing in different muscles, and that the satellite cells are key cells in the regeneration and growth of muscle fibres. Satellite cells are closely associated with muscle fibres, located outside the muscle fibre sarcolemma but beneath the basement lamina. They are quiescent cells, which become activated by stimulation, like muscle fibre injury or increased muscle tension, start replicating and are responsible for the repair of injured muscle fibres and the growth of muscle fibres. The degree of replication is governed by the telomeric clock, which is affected upon excessive bouts of degeneration and regeneration as in muscular dystrophies. The telomeric clock, as in dystrophies, does not seem to be a limiting factor in ageing of human muscle. The number of satellite cells, although reduced in number in aged human muscles, has enough number of cell divisions left to ensure repair throughout the human life span. We propose that an active life, with sufficient general muscular activity, should be recommended to reduce the impairment of skeletal muscle function upon ageing.
Learn Faster Today Improve your study skills
Author information
Author/s: Thornell, L-E (LE); Lindström, M (M); Renault, V (V); Mouly, V (V); Butler-Browne, G S (GS);
Affiliation: Department of Integrative Medical Biology, Section for Anatomy, 901 87 Umeå, Sweden. lars-eric.thornell(-atsign-)anatomy.umu.se
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Scandinavian journal of medicine & science in sports (Scand J Med Sci Sports), published in Denmark. (Language: eng)
Reference: 2003-Feb; vol 13 (issue 1) : pp 48-55
Dates: Created 2003/01/21; Completed 2003/04/29; Revised 2006/11/15;
PMID: 12535317, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.