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| Research article summary (published 29 Sep 2002): |
Salivary cortisol day profiles in elderly with mild cognitive impairment.
Full Abstract
It is unknown whether hypothalamus-pituitary-adrenal (HPA) axis dysfunction is associated with the memory impairments observed among elderly participants with mild cognitive impairment (MCI), a group considered at increased risk for Alzheimer's disease (AD). Therefore, salivary cortisol levels were measured at six points over the course of the day while at-home in MCI participants (n=16), normal elderly (n=28), and young controls (n=14). Results revealed that MCI participants did not show elevated salivary cortisol levels. The 9 a.m. cortisol level of the MCI group was significantly lower than the 9 a.m. level of the young controls, but did not differ from those of the normal elderly group. In contrast to the other two groups, within the MCI group mean cortisol levels were inversely related to immediate recall of paragraphs. No association was observed between mean cortisol levels and performance in paired associates and digit span. Whether cortisol levels, in conjunction with other factors, such as hippocampal volume, will lead to improved prediction of future decline to AD in participants with MCI remains to be established in longitudinal studies.Copyright 2002 Elsevier Science Ltd.
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Author information
Author/s: Wolf, Oliver T (OT); Convit, Antonio (A); Thorn, Elissa (E); de Leon, Mony J (MJ);
Affiliation: Center for Brain Health, Neuroimaging Laboratory, New York University School of Medicine, 560 First Avenue, NY, New York 10016, USA.
Grants: M01 RR00096 (Agency:United States NCRR) ; R01-AG-12101 (Agency:United States NIA) ; R01-AG17115 (Agency:United States NIA)
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Psychoneuroendocrinology (Psychoneuroendocrinology), published in England. (Language: eng)
Reference: 2002-Oct; vol 27 (issue 7) : pp 777-89
Dates: Created 2002/08/16; Completed 2002/11/13; Revised 2007/11/14;
PMID: 12183214, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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