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| Research article summary (published 30 Jul 2003): |
The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal.
Full Abstract
To study the behavior of cerebral physiological parameters and to further the understanding of the functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) effect, multisource frequency-domain near-infrared and BOLD fMRI signals were recorded simultaneously during motor functional activation in humans. From the near-infrared data information was obtained on the changes in cerebral blood volume and oxygenation. To relate our observations to changes in cerebral blood flow the well-known "balloon" model was employed. Our data showed that the deoxyhemoglobin concentration is the major factor determining the time course of the BOLD signal. The increase in cerebral blood oxygenation during functional activation is due to an increase in the velocity of blood flow, and occurs without significant swelling of the blood vessels.
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Author information
Author/s: Toronov, Vlad (V); Walker, Scott (S); Gupta, Rajarsi (R); Choi, Jee H (JH); Gratton, Enrico (E); Hueber, Dennis (D); Webb, Andrew (A);
Affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA. toronov(-atsign-)uiuc.edu
Grants: CA 57032 (Agency:United States NCI) ; DA 14111 (Agency:United States NIDA) ; RR 10966 (Agency:United States NCRR)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Aug; vol 19 (issue 4) : pp 1521-31
Dates: Created 2003/09/01; Completed 2003/10/23; Revised 2007/11/14;
PMID: 12948708, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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