Research article summary:

The role of prenatal stress in the etiology of developmental behavioural disorders.

Abstract Extract:
Substantial evidence from preclinical laboratory studies indicates that prenatal stress (PS) affects the hormonal and behavioural development of offspring. In the following review, the effects of PS in rodents and non-human primates on ... (Full abstract text below)

Published 2002Jun in Journal: Neurosci Biobehav Rev (Language : eng)

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1. Neurosci Biobehav Rev. 2002 Jun;26(4):457-70

The role of prenatal stress in the etiology of developmental behavioural disorders.

Kofman O

Department of Behavioural Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, 84105 Beersheva, Israel. kofman@bgumail.bgu.ac.il

Substantial evidence from preclinical laboratory studies indicates that prenatal stress (PS) affects the hormonal and behavioural development of offspring. In the following review, the effects of PS in rodents and non-human primates on hypothalamic-pituitary-adrenal (HPA) reactivity to stress, morphological changes in the brain, motor behaviour and learning are surveyed. PS has been found to alter baseline and stress-induced responsivity of the HPA axis and levels and distribution of regulatory neurotransmitters, such as norepinepherine, dopamine, serotonin and acetylcholine and to modify key limbic structures. In rodents and non-human primates, PS affected learning, anxiety and social behaviour. The relevance of these findings to humans is discussed with respect to (a) the effect of administration of exogenous corticosteroids in pregnancy and (b) maternal state and trait anxiety during gestation and its relation to foetal autonomic regulation as putative predisposing factors in the pathogenesis of behavioural developmental delays in children.

PMID : 12204192 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Ora	Kofman	O

Affiliation: Department of Behavioural Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, 84105 Beersheva, Israel. kofman@bgumail.bgu.ac.il

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MESH categories and related page links

This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.

Category links from this article:

Animals
Arginine Vasopressin - metabolism
Behavior, Animal - drug effects, physiology
Brain - drug effects, embryology, pathology
Child, Preschool
Corticotropin-Releasing Hormone - metabolism
Dopamine - adverse effects, deficiency
Female
Glucocorticoids - pharmacology, physiology
Hormones - adverse effects, secretion
Humans
Hypothalamo-Hypophyseal System - drug effects, metabolism, physiopathology
Infant
Infant, Newborn
Learning - physiology
Locomotion - physiology
Male
Mental Disorders - etiology, physiopathology, psychology
Motor Activity - physiology
Neurotransmitter Agents - adverse effects, metabolism
Paraventricular Hypothalamic Nucleus - metabolism
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Sex Factors
Stress, Psychological - physiopathology

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