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| Research article summary (published 30 May 2003): |
The role of lipid-lowering drugs in cognitive function: a meta-analysis of observational studies.
Full Abstract
STUDY
OBJECTIVE:
To quantify the risk of cognitive impairment with use of lipid-lowering drugs.
DESIGN AND DATA SOURCES:
Literature search through MEDLINE and EMBASE databases; data from seven observational studies were analyzed.
MEASUREMENTS AND MAIN RESULTS:
We quantified the risk of cognitive impairment first with the use of any lipid-lowering drug, and then specifically with the statins, using the random effects model. We tested for heterogeneity using the Q statistic as well as quantitatively using the Ri statistic. All seven studies provided data for statin users, and five provided data only on use of lipid-lowering drugs. Compared with patients not receiving lipid-lowering drugs, the relative risk of cognitive impairment with any lipid-lowering drug was 0.62 but was not statistically significant (95% confidence interval [CI] 0.28-1.38), and the relative risk with statins was 0.43 and was statistically significant (95% CI 0.31-0.62).
CONCLUSION:
Lipid-lowering drugs--in particular, the statins--seem to lower the odds of developing cognitive impairment. Randomized, controlled trials are needed to address the efficacy of these agents specifically in different types of dementia.
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Author information
Author/s: Etminan, Mahyar (M); Gill, Sudeep (S); Samii, Ali (A);
Affiliation: Pharmacoepidemiology Unit, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
Journal and publication information
Publication Type: Journal Article; Meta-Analysis
Journal: Pharmacotherapy (Pharmacotherapy), published in United States. (Language: eng)
Reference: 2003-Jun; vol 23 (issue 6) : pp 726-30
Dates: Created 2003/06/24; Completed 2003/10/06; Revised 2004/11/17;
PMID: 12820814, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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