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| Research article summary (published 30 Dec 2002): |
A role of the basal ganglia in movement: the effect of precues on discrete bi-directional movements in Parkinson's disease.
Full Abstract
The effect of a precue on improving movement initiation (i.e., reaction time; RT) is well understood, whereas its influence on movement execution (i.e., movement time; MT) has rarely been examined. The current study investigated the influence of a directional precue (i.e., left vs. right) on the RT and MT of simple and discrete bi-directional movements in a large sample of Parkinson's disease patients and healthy control participants. Both patients and controls were tested twice, with testing sessions separated by 2 hours. Patients were tested first following an overnight levodopa withdrawal and again after they had taken their medication. Both patients and controls demonstrated a significant RT improvement when information was provided in advance. MT in both healthy participants and medicated patients was, however, slower with the provision of advance information, while unmedicated patients showed no significant MT effects. These results suggest that while the basal ganglia may not be involved in motor program selection, they may dynamically modulate movement execution.
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Author information
Author/s: Johnson, Andrew M (AM); Vernon, Philip A (PA); Almeida, Quincy J (QJ); Grantier, Linda L (LL); Jog, Mandar S (MS);
Affiliation: Faculty of Health Sciences at the University of Western Ontario, London, ON, Canada N6A 3K7.
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article
Journal: Motor control (Motor Control), published in United States. (Language: eng)
Reference: 2003-Jan; vol 7 (issue 1) : pp 71-81
Dates: Created 2003/01/21; Completed 2003/04/30; Revised 2004/11/17;
PMID: 12536163, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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