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| Research article summary (published 27 Feb 2002): |
The role of the basal forebrain in episodic memory retrieval: a positron emission tomography study.
Full Abstract
Human lesion data indicate that the basal forebrain or orbitofrontal cortex, or both, as well as medial temporal and diencephalic structures, is important for normal memory and that its disruption causes the pure amnesic syndrome, in which episodic memory is grossly impaired while other kinds of memory remain preserved. Among these critical areas, functional imaging studies have so far failed to detect activation of the basal forebrain, although activation in the nearby orbitofrontal cortex has been reported during episodic memory retrieval. We employed positron emission tomography to elucidate the neural basis of episodic memory recall utilizing two types of time cues and successfully detected activity in the basal forebrain for the first time. Specifically, recall of previously memorized words from temporal cues was associated with activity in the basal forebrain, right middle frontal gyrus, right superior temporal gyrus, and posterior cingulate gyrus, whereas their recall from person cues was associated with activity in the left insula, right middle frontal gyrus, and posterior cingulate gyrus. Furthermore, percentage increases of regional blood flow in the basal forebrain were correlated with behavioral data of successful recall. Our results provide clear evidence that the human basal forebrain has a specific role in episodic memory recall, especially that from time-contextual information.©2002 Elsevier Science (USA).
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Author information
Author/s: Fujii, Toshikatsu (T); Okuda, Jiro (J); Tsukiura, Takashi (T); Ohtake, Hiroya (H); Miura, Rina (R); Fukatsu, Reiko (R); Suzuki, Kyoko (K); Kawashima, Ryuta (R); Itoh, Masatoshi (M); Fukuda, Hiroshi (H); Yamadori, Atsushi (A);
Affiliation: Division of Neuropsychology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2002-Mar; vol 15 (issue 3) : pp 501-8
Dates: Created 2002/02/18; Completed 2002/04/22; Revised 2006/11/15;
PMID: 11848693, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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