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| Research article summary (published 30 Aug 2002): |
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Response slowing in Parkinson's disease: a psychophysiological analysis of premotor and motor processes.
Full Abstract
The mechanisms responsible for reaction time slowing in Parkinson's disease were investigated using movement-related potentials in a choice reaction time task. Parkinson's disease patients and control subjects were required to respond with the left or right hand to indicate whether a visual stimulus was relatively large or small. The difficulty of the size discrimination was manipulated, as was the complexity of the manual response (single key press versus sequence of three key presses). Behavioural responses of Parkinson's disease patients were slower than those of control subjects, especially when complex responses were required. Moreover, the timing of movement-related potentials indicated that motor processes clearly required extra time, relative to control subjects, for Parkinson's disease patients making complex responses. In addition, delayed onset of the movement-related potentials indicated that one or more premotor processes are also slowed in these patients.
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Author information
Author/s: Low, Kathy A (KA); Miller, Jeff (J); Vierck, Esther (E);
Affiliation: Beckman Institute, University of Illinois, Urbana, IL 61821, USA. lowka@uiuc.edu
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Brain : a journal of neurology (Brain), published in England. (Language: eng)
Reference: 2002-Sep; vol 125 (issue Pt 9) : pp 1980-94
Dates: Created 2002/08/16; Completed 2002/09/17; Revised 2006/11/15;
PMID: 12183344, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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