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| Research article summary (published 30 Jan 2003): |
Reproducibility of the word frequency effect: comparison of signal change and voxel counting.
Full Abstract
We determined the reproducibility of both the direction and the effect size of the word frequency effect (WFE) as it relates to associative semantic judgments. Sixteen volunteers were scanned twice. At the group level of analysis, signal change and voxel counting could both reproducibly detect the existence of a WFE. However, signal change data showed less intersession variation, particularly in the left inferior frontal gyrus. The effect size of WFE was well reproduced only with signal change measurements. In consideration of the signal change data, statistical threshold did not have a major effect on the detection or determination of the effect size. In general, while the direction of the WFE was reasonably reproducible at the individual level, the effect size was far less well reproduced. These findings suggest that with existing techniques, fMRI may be used to track changes in brain activation stemming from improvement in language proficiency at the group level but not at the individual level.
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Author information
Author/s: Chee, Michael W L (MW); Lee, Hwee Ling (HL); Soon, Chun Siong (CS); Westphal, Christopher (C); Venkatraman, Vinod (V);
Affiliation: Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, c/o Singapore General Hospital, 7 Hospital Drive #01-11, Singapore 169856. mchee@pacific.net.sg
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Feb; vol 18 (issue 2) : pp 468-82
Dates: Created 2003/02/21; Completed 2003/04/11; Revised 2006/11/15;
PMID: 12595200, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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