 |
| Research article summary (published 30 Jul 2002): |
|
Free Full Text! See links below |
Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humans.
Full Abstract
OBJECTIVE:
The purpose of this study was to investigate the effect of enhanced noradrenergic activity on memory consolidation in humans.
METHOD:
Thirty healthy subjects (21 men and nine women) viewed a series of 12 slides that depicted an emotionally arousing story. Five minutes after viewing the slides, subjects received either intravenous yohimbine or intravenous placebo in a double-blind randomized fashion. Multiple blood samples were drawn for determining plasma free 3-methoxy-4-hydroxyphenylglycol (MHPG). One week later subjects took a surprise memory test for the slides.
RESULTS:
There was no significant difference in memory score between yohimbine and placebo groups. Linear regression revealed a significant effect of MHPG on memory score for the group as a whole (subjects who had received yohimbine and those who had received placebo) and for the placebo group alone.
CONCLUSIONS:
These findings strengthen support for the hypothesis that enhanced memory for emotionally arousing events in humans depends critically on postlearning adrenergic modulation.
Learn Faster Today Improve your study skills
Author information
Author/s: Southwick, Steven M (SM); Davis, Michael (M); Horner, Beverly (B); Cahill, Larry (L); Morgan, Charles A (CA); Gold, Paul E (PE); Bremner, J Douglas (JD); Charney, Dennis C (DC);
Affiliation: Department of Psychiatry, Yale University School of Medicine, CT, USA. Steven.Southwick@med.va.gov
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)
Reference: 2002-Aug; vol 159 (issue 8) : pp 1420-2
Dates: Created 2002/08/02; Completed 2002/08/27; Revised 2006/11/15;
PMID: 12153837, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.