 |
| Research article summary (published 29 Sep 2002): |
Regional cerebral perfusion abnormalities in attention deficit/hyperactivity disorder. Statistical parametric mapping analysis.
Full Abstract
OBJECTIVE:
A voxel based investigation of cerebral blood flow was conducted to identify brain function differences in the resting state between children with Attention Deficit Hyperactivity Disorder (ADHD) and normal controls.
METHOD:
Using DSM-IV criteria, we selected 40 children with pure ADHD by various assessment scales, psychometric tools and a neuropsychological battery. All patients were examined by (99m)Tc-HMPAO brain SPECT. Seventeen normal controls were recruited from age, sex, and IQ-matched children whose previous SPECT, MRI, EEG and psychometric and neuropsychological findings had been normal. Using SPM methods, we compared SPECT images of ADHD patients and those of 17 control subjects on a voxel by voxel basis using t-statistics. Voxels with a p-value of less than 0.01 were considered to be significantly different.
RESULT:
Decreased cerebral blood flow in right lateral prefrontal cortex, right middle temporal cortex, both orbital prefrontal cortex and both cerebellar cortices were found in children with ADHD compared to the controls. In addition, the ADHD group showed increased blood flow in some parietal and occipital lobes (posterior brain regions) compared to the control group.
CONCLUSION:
Although the results should be interpreted cautiously, this study confirms the presence of functional defects in the prefrontal cortex and reports new problems in the limbic area, somatosensory areas and in the cerebellum during the resting state of brains of ADHD children.
Learn Faster Today Improve your study skills
Author information
Author/s: Kim, Boong-Nyun (BN); Lee, Jae-Sung (JS); Shin, Min-Sup (MS); Cho, Soo-Churl (SC); Lee, Dong-Soo (DS);
Affiliation: Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital, 28 Yungundong, Chongrogu, Seoul, Korea. kbn1@snu.ac.kr
Journal and publication information
Publication Type: Journal Article
Journal: European archives of psychiatry and clinical neuroscience (Eur Arch Psychiatry Clin Neurosci), published in Germany. (Language: eng)
Reference: 2002-Oct; vol 252 (issue 5) : pp 219-25
Dates: Created 2002/11/26; Completed 2003/05/12; Revised 2006/11/15;
PMID: 12451463, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.